Abstract
Phosphoribosylpyrophosphate synthetase-1 [PRPS-1; EC=2.7.6.1) catalyzes the phosphoribosylation of ribose 5...
Highlights
Adenosine, high concentration of SO42- was acting as the inhibitors for the PRPS-1 (98,7634±1,2450,93,2074±0,0932; p
In the settings of the GB high concentrations of SO42- were diminishing the activity of PRPS-1 in the experimental GB settings in comparison with the control
The inhibitors of PRPS-1 might be useful in the setting of the cancer prevention, for GB
Summary
Phosphoribosylpyrophosphate synthetase-1 [PRPS-1; EC=2.7.6.1) catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for the salvage pathways of purine and pyrimidine, pyridine nucleotide cofactors NAD and NADP, the amino acids histidine and tryptophan biosynthesis [1,2]. It is regulative enzyme, responsible for the synthesis of purine and pyrimidine. Metal ions are vital for functionality (metallo-enzyme activity, protein stabilization etc.) and maintenance of nervous tissue. Changes in aggregation properties (a-synuclein and amyloid-b) lead to complex protein formation owing to the presence of aluminium, copper and iron [3]
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