Abstract
A series of three monoclonal antibodies to human lymphoid cell surface determinants was utilized to characterize the effector population for natural killing (NK) and antibody-dependent cellular cytotoxicity (ADCC). The first antibody, termed anti-T3, was reactive with all peripheral T cells (T3 +); a second defined an invariant region of the human Ia antigen found on all B cells and a fraction of monocytes and Null cells (Ia +); and a third, anti-M1, reacted with circulating monocytes (MI +). Complement-mediated lysis was employed to eliminate M1 +, T3 +, and/or Ia + cells. It was found that removal of the M1 + population markedly reduced ADCC as well as NK. In contrast, lysis of T3 + and Ia + cells enriched for both functions. These observations suggest that the major effectors of NK and ADCC among resting peripheral blood mononuclear cells are restricted to the M1 +, Ia − population.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
