Delineating association between polymorphic variants of vitamin D receptor (VDR) gene and multiple myeloma disease in Indian population.

Abstract

Multiple myeloma (MM) is characterized by excessive proliferation and accumulation of abnormal plasma cells infiltrating the bone marrow microenvironment. It is characterized by secretion of atypical monoclonal immunoglobulin (M protein) by plasma cells in blood or urine, anemia, hypercalcemia, renal dysfunction, and bone pain accompanied with pathological fractures. Approximately 70% of MM patients display skeletal abnormalities at diagnosis and after diagnosis nearly 85% patients develop bone lesions during the course of disease.