Abstract
AbstractThe TRPC4 ion channel is expressed extensively in corticolimbic and a subpopulation of midbrain dopamine neurons. While TRPC4 knockout (KO) rats exhibit reduced sociability and social exploration, little is known about the role of TRPC4 in motivation and learning. To identify a function for TRPC4 channels in learning processes we tested TRPC4 KO and normal wild type (WT) rats. TRPC4 KO and WT rats exhibited no differences in Y--maze learning or simple discrimination learning. Furthermore, on a more complex serial reversal shift task designed to assess strategic learning where the reward and non--reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats performed equally well. Finally, we found no performance differences when using a conditional reversal shift task where a tone signals the reversal of reward and non-reward cues within sessions. These data suggest that although TRPC4 channels may play a role in social interaction/anxiety they exert a minimal role in simple and complex strategic learning.
Highlights
Complex Strategic Learning For complex learning we chose a serial reversal shi paradigm (SRS) where S+ and S- are repeatedly reversed between blocks of training
Since we found no di erences between KO and wild type (WT) rats on this task we progressed to a more di cult conditional reversal shi (CRS) task where S+ and S- were reversed contingent upon a tonal cue within session
We found no di erences between TRPC4 and KO rats performance on this task
Summary
Deletion of the trpc[4] gene and its role in simple and complex strategic learning. William D. On a more complex serial reversal shift task designed to assess strategic learning where the reward and non-reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats performed well. We found no performance differences when using a conditional reversal shift task where a tone signals the reversal of reward and non-reward cues within sessions These data suggest that TRPC4 channels may play a role in social interaction/anxiety they exert a minimal role in simple and complex strategic learning. We examined the behavioral effects of TRPC4 ion channels by comparing learning in TRPC4 KO and WT rats on simple Y-maze learning and complex strategic learning using serial reversal shi and conditional reversal shi paradigms using natural water reward
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