Abstract
Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber. Unconditioned suppression of magazine responding to visual stimuli was measured in wild-type and GluA1 knockout mice. Wild-type mice showed less suppression to a stimulus that had been presented recently than to a stimulus that had not. GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus. Thus, GluA1 is not necessary for encoding, but affects the way that short-term memory is expressed.
Highlights
The GluA1 subunit of the AMPA receptor is a key mediator of hippocampal synaptic plasticity (Zamanillo et al 1999)
To further investigate the role of GluA1 in short-term memory we tested whether the GluA1 knockout deficit extended to discrete nonspatial visual stimuli in a spontaneous recognition memory task
Mice were tested in operant chambers (15.9 × 14.0 × 12.7 cm; ENV-307A, Med Associates), enclosed in sound-attenuating cubicles (ENV-022MD, Med Associates) using Med-PC IV software (Med Associates)
Summary
The GluA1 subunit of the AMPA receptor is a key mediator of hippocampal synaptic plasticity (Zamanillo et al 1999). GluA12/2 mice show long-term spatial recognition, but impaired short-term recognition memory (Sanderson et al 2007, 2009). To examine the role of short-term memory mice received trials that consisted of a series of two stimulus presentations. By using this manipulation it is possible to test stimulus-specific effects of short-term memory on responding to the visual stimuli.
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