Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

Abstract

(Cell Reports 20, 881–894; July 25, 2017) In the originally published version of this article, the Supplemental Experimental Procedures were accidentally omitted. The Supplemental Experimental Procedures now appear with the article online. The authors regret this error. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte FunctionFidler et al.Cell ReportsJuly 25, 2017In BriefFidler et al. show that glucose metabolism is essential for platelet production, activation, and clearance. Their findings reveal complementary roles for glycolysis versus mitochondrial metabolism in platelet viability. Blocking both metabolic pathways leads to complete clearance of platelets from the circulation, due to calcium overload and calpain activation. Full-Text PDF Open Access