Deletion of Chromosome 11 in Babies With Michelin Tire Syndrome-Reply

Abstract

In Reply.— We wish to thank Dr Burgdorf for his interest in our case report. For those not familiar with genetic coding, we used the word abnormal to emphasize that the deletion was not a finding. We are sorry for any confusion that this may have caused. There are, of course, no normal deletions. The cytogenetic studies performed were cultivated blood lymphocytes, and the banding technique was Giemsa banding. Thirty plates were examined, and the deletion was found in all of them. The deletion of chromosome 11 involved the short arm only, and the correct reporting of the chromosome karyotype should read 46, XX, del (11) (g21g23). In these types of chromosome problems, family studies are indicated, especially when looking for a balanced translocation carrier status in a parent. However, we were unable to obtain these studies in the parents, and, therefore, the information on the patient is not