Abstract
Background Gastrointestinal (GI) complications such as constipation, diarrhea and gastroparesis are common in hereditary transthyretin (ATTR) amyloidosis. The mechanisms behind these disturbances have not been fully elucidated and the patients’ small bowel function remains largely unexplored. The aim of the present study was to compare the small bowel motility in patients with hereditary ATTR amyloidosis with that in non-amyloidosis controls.
Highlights
Gastrointestinal (GI) complications such as constipation, diarrhea and gastroparesis are common in hereditary transthyretin (ATTR) amyloidosis
Patients with hereditary ATTR amyloidosis undergoing evaluation for liver transplantation were consecutively selected for manometry (n = 19), and for each patient three age and gender matched controls (n = 57) with functional GI disorders were selected for comparison
Lateonset cases showed a longer delay in octreotide response, but no major difference related to gender, presence of GI symptoms, PND score or TTR mutation was found for any of the variables
Summary
The aim of the present study was to compare the small bowel motility in patients with hereditary ATTR amyloidosis with that in non-amyloidosis controls
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