Abstract
Lactate constitutes the primary gluconeogenic precursor in healthy humans at rest and during low-intensity exercise. Data on the interactions between lactate and glucose metabolisms during recovery after short-duration high-intensity exercise are sparse. The aim of the present study was to describe blood glucose ([glucose]b) and lactate ([lactate]b) concentration curves during recovery following short-duration high-intensity exercise. Fifteen healthy Cameroonian subjects took part in the study and performed successively (i) an incremental exercise to exhaustion to determine maximal work rate (Pmax) and (ii) a 2-min 110% Pmax exercise after which blood lactate and glucose concentrations were measured during the 80-min passive recovery. In response to the 2-min 110% Pmax exercise, [glucose]b remained stable (from 4.93 ± 1.13 to 4.65 ± 0.74 mmol.L−1, NS) while [lactate]b increased (from 1.35 ± 0.36 to 7.87 ± 1.66 mmol.L−1, p < 0.0001). During recovery, blood lactate concentrations displayed the classic biphasic curve while blood glucose concentrations displayed a singular shape including a delayed and transitory rebound of glycemia. This rebound began at 27.7 ± 6.2 min and peaked at 6.78 ± 0.53 mmol.L−1 at 56.3 ± 9.7 min into recovery. The area under the curve (AUC) of [lactate]b during the rebound of glycemia was positively correlated with the peak value of glycemia and the AUC of [glucose]b during the rebound. In conclusion, the delayed rebound of glycemia observed in the present study was associated with lactate availability during this period.
Highlights
For almost a century, lactate has been known as a major gluconeogenic precursor
It has been demonstrated that the main fate of lactate is oxidation, lactate serves as the primary gluconeogenic precursor [8,9,10,11,12]
The blood glucose curves displayed a singular shape, in which after a brief and transitory burst followed by a return to near resting blood glucose concentration, a delayed rebound was observed
Summary
Lactate has been known as a major gluconeogenic precursor. numerous studies observed a splanchnic uptake of lactate during exercise and subsequent recovery [1,2,3,4]. The Cori (or lactate) cycle, originally described in 1929, involves the conversion of glucose (and/or glycogen) to lactate in the skeletal muscle and the conversion back to Glucose and Lactate Recovery Curves glucose (and/or glycogen) from lactate in the liver [5] These glucose-lactate metabolism interactions have been observed in various clinical contexts. It has been demonstrated that the main fate of lactate is oxidation, lactate serves as the primary gluconeogenic precursor [8,9,10,11,12] This is true at rest, during moderate-intensity exercise, and during recovery [8,9,10,11,12]. While glucose and lactate metabolism interactions, as part of the lactate shuttle concept [20], are well-documented in the literature at rest, during moderate-intensity exercise, and its subsequent recovery [21], data during recovery following short-duration high-intensity exercise are, by contrast, sparse
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