Abstract
Extract: Retarded growth, lethargy, motor retardation, and tremor were observed in all offspring from dams subjected to vitamin B6 deficiency during pregnancy or shortly after delivery of litters. Renal development in these animals was delayed and the degree of retardation depended upon the time of initiation of the deficient diet. Uremia, lethargy, motor retardation, and tremor coincided with this maturational delay. The degree of reduction of vitamin B6 in liver and brain bore no systematic relation to the degree of deprivation. Moreover, all symptoms were consistent with the effects of uremia alone. Although cellular mitotic rates were clearly decreased in deprived animals, there was no apparent failure of glomerular neogenesis from diverse vascular, tubular, and subcapsular cellular components.Speculation: Retarded growth, lethargy, motor retardation, and tremor, observed in vitamin B6-deficient young, were the secondary consequences of uremia which resulted from retarded renal development. This suggests a possible role of vitamin B6 in kidney morphogenesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
