Delayed maturation of P2 flash visual evoked potential (VEP) latency in newborns of gestational diabetic mothers

Abstract

The prevalence of gestational diabetes mellitus (GDM) has rapidly increased, yet few prior studies have investigated parameters of early brain development in infants born to gestational diabetic mothers. The present study assessed visual evoked potentials (VEPs) in healthy infants born to gestational diabetic mothers and matched controls. After exclusions, in this prospective study we examined VEPs in 73 neonates between 37weeks and 41weeks gestation at birth (n=37 infants of gestational diabetic mothers). Stroboscopic flashes were presented through closed eyelids during passive electroencephalography (EEG) recording to derive VEP waveforms during natural sleep. There was a statistically significant moderate correlation between gestational age at birth and P2 latency of the flash VEP where P2 latency significantly decreased with increasing gestational age (Pearson's R(73)=-0.32, p<.01). There was also a significant moderate correlation between postnatal age (hours of life) and P2 latency of the flash VEP where P2 latency significantly decreased with increasing postnatal age (Pearson's R(73)=-0.23, p<.05). When controlling for gestational age at birth, postnatal age, and sex, there was a significant effect of group (GDM-exposed vs. control) on P2 latency of the flash VEP (p<.05). Infants of gestational diabetic mothers had a significantly longer P2 latency (M: 215.29±SD: 2.58ms) than controls (M: 206.41±SD: 2.62ms). Our findings suggest P2 flash VEP latency is a potential measure of cortical maturation and marker of immature development in infants of gestational diabetic mothers.