Delayed inhibition of epidermal DNA synthesis after injection of an aqueous skin extract (chalone).

Abstract

Single or repeated injections of a crude aqueous extract of mouse skin inhibited DNA synthesis in epidermis within 9–12 hours after intraperitoneal injection. Similar injections of water or of an aqueous extract of liver did not affect epidermal DNA synthesis. The delayed inhibition of DNA synthesis suggests that the epidermal chalone may affect the decision of a cell to prepare for DNA synthesis 9–12 hours later.