Abstract
Mice were reared under “normally nourished” or “undernourished” conditions by maintaining litter sizes at 6, 8, or 16 pups, respectively. In two experiments, age-related activity responses to the cholinergic antagonist scopolamine were examined either cross-sectionally or longitudinally from approximately 11 through 25 days of age as a function of nutrition conditions. Although a delayed emergence of scopolamine-induced activity potentiation was found for undernourished mice only in the longitudinal study, attainment of an adultlike drug response pattern occurred later for undernourished mice in both the cross-sectional and longitudinal studies. The results suggest that an impairment of brain cholinergic functioning contributes to developmental deficits in inhibitory control, which have been reported for undernourished young mice.
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