Delayed diagnosis of post-surgical pyoderma gangrenosum: A multicenter case series and review of literature

Abstract

IntroductionPyoderma gangrenosum is a chronic neutrophilic dermatosis which can occur following trauma or surgery and can mimic infection. Surgical intervention can lead to progression of disease. Presentation of casesThis case series describes 3 cases of post-surgical pyoderma gangrenosum with delayed diagnosis from two large medical centers. DiscussionEpidemiology, pathogenesis, clinical and histopathologic presentation, and management of post-surgical pyoderma gangrenosum are discussed with a review of the literature. ConclusionPost-surgical pyoderma gangrenosum (PSPG) can mimic ulcerative disorders including bacterial infection. The diagnosis should be suspected in post-operative wounds with negative bacterial cultures which progress despite broad-spectrum antibiotics and surgical debridement. Recognizing the clinical features of PSPG is fundamental to prevent severe destruction and deformity.