Abstract
Destructive changes and disturbances of spermatogenesis are found to occur in the testes of Wistar rats 1 and 3 months after a single injection of the anthracycline antibiotic pharmorubicin in the maximum permissible dose. The morphological picture normalizes 6 months postinjection. Disturbances in reproductive function are observed as early as 3 months after treatment. The number of dominant lethal mutations rises one month postinjection.
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