Abstract
2063 Background: Conventional MRI is unable to differentiate tumor progression from treatment-induced effects (pseudoprogression/radiation-necrosis) in brain tumor patients, thus significantly impacting patients’ management with no current solution. Methods: We have applied a novel MRI-based methodology for high resolution depiction of tumor/non-tumor tissues. This unique model-independent technique is based on robust MRI sequences acquired with a delay, enabling complete separation between tumor (contrast clearance at the delayed time point) and treatment effects (contrast accumulation) with no overlap. 498 treatment response assessment maps were calculated for 149 patients with primary/metastatic brain tumors and 9 with AVM recruited/followed on study. Results: The maps were validated by comparing pre-surgical maps of 51 patients with primary/metastatic brain tumors who underwent surgery with histology, resulting in 100% sensitivity and 94% specificity to active tumor. This validation confirms that cont...
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