Abstract
Purpose Growth hormone (GH) treatment is recommended to improve growth and psychosocial problems in short stature children born small for gestational age (SGA). Although GH therapy in these patients has been extensively studied, the impact of therapy according to delays in bone age (BA) is not known well. Objective To investigate the effects of GH therapy in SGA patients with short stature according to BA delay. Methods We retrospectively analyzed changes in height SD score (SDS) and BA/chronological age (CA) after 6 and 12 months of GH therapy in patients grouped according to BA delay. We studied 27 SGA children with short stature in the pediatric endocrinology clinic of Kyungpook National University Children's Hospital. Results Of the 27 patients, 9 had <2 years of BA delay, while 18 had >2 years of delay. There were no significant differences between the two groups in terms of gestational age and weight at birth, height SDS, IGF-1 SDS, and growth hormone dosage at the beginning of therapy. However, height SDS increased significantly in the group with >2 years of BA delay after 6 months of GH therapy (−2.50 ± 0.61 vs −1.87 ± 0.82; p=0.037) and 12 months (−2.27 ± 0.70 vs −1.63 ± 0.65; p=0.002). When height SDS was compared between with and without GHD, there were no significant differences. Conclusions Delayed BA (>2 years) may impact the response to GH treatment in SGA children with short stature.
Highlights
Small for gestational age (SGA) is defined as a birth weight of
Increases in Bone age (BA) have been reported in SGA patients with short stature who undergo growth hormone (GH) therapy [17,18,19]; these changes are not associated with age or GH dose [17], bone
No study to date has investigated the effects of GH therapy in association with BA delay in SGA patients with short stature. erefore, the present study aimed to investigate the influence of GH therapy on BA delay in these patients
Summary
Small for gestational age (SGA) is defined as a birth weight of
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