Abstract
The relative importance of two subcortical structures, projecting to the rat's prefrontal cortex, in mediation of delayed-alternation performance, was tested. These structures, the thalamic mediodorsal nucleus and the ventral tegmental area, were lesioned with kainic acid after the rats had learned a spatial delayed-alternation task. It was found that both structures are apparently involved to a similar degree in the performance of this task and that the behavior of both experimental groups differed from that of a sham-operated control group of rats.
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