Abstract
There is considerable evidence for genetic control of aging and longevity. For example, there are major differences in life span between different breeds of domestic dogs, between different inbred lines of laboratory mice, and between lines of mice developed by selection for various phenotypic traits. Studies in yeast, in a round worm, Caenorhabditis elegans, and in the fruit fly, Drosophila melanogaster, provided a wealth of information on the genetic control of aging, including evidence that mutations at specific loci can produce major alterations in the life span. A new term, longevity assurance genes (LAGs), was coined to describe genes involved in the control of the life span. Evidence for the existence of LAGs in yeast, C. elegans, and Drosophila and the effects of mutations at these loci are described in other chapters in this Volume.
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