Abstract
We demonstrate a delaying effect of deep-sea drinking water (DDW) containing enhanced magnesium ion (Mg2 +) and calcium ion (Ca2 +) concentrations on cataract development in Shumiya cataract rats (SCRs). The lenses of SCRs administered DDW-200 (Mg2 +, 200 mg/L, Ca2 +; 71 mg/L) were less opaque than those in SCRs administered purified water (PW). In SCRs administered DDW-200, a decrease in Mg2 + content and an increase in Ca2 + content in the lenses was prevented in comparison with SCRs administered PW. Nitric oxide (NO) levels in the lenses of SCRs administered DDW-200 were lower than those in SCRs administered PW. In conclusion, the administration of DDW-200 to SCRs has a potent delaying effect on cataract development, possibly due to preventing an increase in NO levels in the lens.
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