Abstract
AbstractThe selective dehydrogenative electrochemical activation of benzylic positions by 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP) and subsequent cyanation is presented for the first time. Herein, we report a sustainable, scalable, and metal‐free dehydrogenative benzylic cyanation protocol. Valuable 2‐phenylacetonitrile derivatives are accessible in the presence of a cyanide source and an electrolytically‐derived HFIP ether. The direct application of electricity enables a safe and environmentally benign chemical transformation, since oxidizers are replaced by electricity.
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