Abstract
Amyloid β (Aβ) peptides produced from the amyloid precursor protein, a transmembrane protein, are neurotoxic and blocking the neurotoxicity may lead to prevention of Alzheimer's disease (AD). Here we tested whether Aβ25-35-induced cognitive decline is rescued by treatment with dehydroeffusol, a phenanthrene isolated from Chinese medicine Juncus effusus. Dehydroeffusol (5 ~ 15mg/kg body weight) was orally administered to mice for 6days and Aβ25-35 (2mM) was injected at the rate of 1μl/min for 3min into the lateral ventricle. Y-maze test was performed after dehydroeffusol administration for 12days. Aβ25-35 impaired learning and memory in the test, while the impairment was dose-dependently rescued by dehydroeffusol administration. The present study indicates that treatment with dehydroeffusol is effective for rescuing Aβ25-35-induced cognitive decline.
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