Degree of nephrotoxicity after intermediate or high-dose cisplatin-based chemoradiotherapy (CRT) in patients with locally advanced head and neck cancer (LAHNC).

Abstract

6056 Background: CRT with cisplatin 100 mg/m2 on days 1, 22, 43 (cis100) is standard treatment for LAHNC and nasopharyngeal cancers (NPC) patients (pts). An alternative CRT schedule consists of cisplatin 40 mg/m2 weekly during six weeks (cis40). A direct prospective comparison of these 2 schedules has not been performed, yet. Data on the influence of these schedules on cisplatin-based nephrotoxicity are scarce. This study compared the occurrence of cisplatin-induced nephrotoxicity between these 2 CRT schedules. Methods: All pts treated with CRT for LAHNC or NPC from 2003 until 2011 in the Radboud university medical center were studied retrospectively. One hundred forty-four LAHNC/NPC pts were included, of whom 40 received cis100 and 104 received cis40. Serum creatinine at baseline and maximal rise during treatment were collected. An increase of 25% was established as clinically relevant. Nephrotoxicity was scored according to both the CTCAE version 3.0 and version 4.03. Results: Baseline serum creatinine ...