Abstract
BackgroundDegraded and osteogenic property of coated magnesium alloy was evaluated for the fracture fixation in rabbits.MethodsMagnesium alloy AZ31 with a different coating thickness by microarc oxidation was used, and the bilateral radial fracture model was created by the bite bone clamp. Thirty-six New Zealand white rabbits in weight of 2.5~3.0 kg were randomly divided into A, B, and C groups at four time points and other 3 rabbits as the control group without magnesium alloy. Coated magnesium alloy AZ31 was implanted on the fracture and fixed with silk thread. Indexes such as general observation, histology, X-ray, hematology, and mechanical properties were observed and detected at 2nd, 4th, 8th, and 12th week after implantation.ResultsFracture in each rabbit was healed at 12th week after implantation. Among the three groups, the best results of general observation, histology, and X-ray appeared in A group without coating. However, A group showed the worst results from the perspective of mechanical properties about tensile strength and flexural strength, which failed to reach that of the natural bone at the 12th week. Comprehensive results displayed that C group with 20-μm coating was better than others in mechanical properties, while there is no difference between B and C groups in hematology.ConclusionsDegradation rate is inversely proportional to the coating thickness. And magnesium alloy with a 20-μm coating is more suitable for the fracture fixation.
Highlights
Degraded and osteogenic property of coated magnesium alloy was evaluated for the fracture fixation in rabbits
The implanted magnesium alloy AZ31 was coated with a thin layer of fibrous tissue at four time points and new bone tissue appeared from 4th week, while A group was with the best healing situation and B group was better than C group
At the 12th week, the magnesium alloy appeared with severe corrosion and became thin but not broken in A group, the magnesium alloy matrix was corroded seriously in B group with a coverage less than 50 %, and a large area of coating disappeared and the magnesium alloy matrix was only lightly corroded with a coverage of more than 50 %
Summary
Degraded and osteogenic property of coated magnesium alloy was evaluated for the fracture fixation in rabbits. Due to the rapid degradation of magnesium alloy in natural conditions, the application of it in clinical practice is limited for a long time [4]. In 1990, Payr first proposed that the magnesium alloy can be made into an internal fixation material such as a needle, wire, nail, and plate and used in fixed skeletal. In order for magnesium to be considered an acceptable biomaterial for tissue and bone replacement and regeneration, improvement of its corrosion resistance is needed. There have been methods developed in the art for the purpose of improving the corrosion resistance of magnesium. Known methods include element alloying and surface modification or coating [6]
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