Abstract
In this drug storage stability surveillance, we evaluated and compared the effects of different storage temperatures and ventilation conditions on the level of active pharmaceutical ingredient (API) of an ACT- based antimalarial (XYZ) drug formulation. The drug which contains artemether and lumefantrine is marketed by drug vendors in Lafia, Nasarawa state. From the analyses carried out, the concentration of lumefantrine (estimated with UV-Vis spectrophotometer) as well as Artemether (analyzed using HPLC) in the drug shows slightly different values which are statistically insignificant when investigated for the effects of storage temperatures and ventilation conditions. Drugs from pharmaceutical stores equipped with fan without cross ventilation (FNV), fan with inadequate ventilation (OCV), fan with cross ventilation (FCV) and fan with air conditioner (ACF) gave lumefantrine level of 494.30, 438.68, 472.48 and 488.68 mg respectively as against the label’s acclaimed 480 mg lumefantrine. The results for artemether includes: FNV (76.93), OCV (79.49), FCV (80.61) and ACF (73.55) milligrammes respectively as against 80 mg drug label claim. Reported values fell within the recommended (90%-120%) NAFDAC acceptable values for drug stability.
Highlights
Drug storage is among the pharmacist’s most important responsibilities
We evaluate and compare the effects of different storage temperature and ventilation conditions on International Journal of Biomedical Materials Research 2017; 5(3): 29-36 the active pharmaceutical ingredient (API) of an Artemisinin-based combination therapies (ACTs)- based antimalarial drug sold by drug vendors, availing public health stakeholders with information relevant to best storage practice for ACT- based antimalarial drugs
This finding suggests that countries in sub-Saharan Africa with predominantly tropical weather condition and poor electricity supply can afford to store AL-ACT- based antimalarial drug within the condition of this work and still get the desired drug quality for combating malaria
Summary
Drug storage is among the pharmacist’s most important responsibilities. adequate methods to assure that these responsibilities are met must be developed and implemented. Lumefantrine, a fluorine (benzindene) derivative (a-(dibutylaminomethyl) - 2, 7dichloro-9-(p-chlorobenzylidene)-5-fluorenemethanol), is an aryl-amino alcohol with intriguing similarities to other antimalarials (quinine, halofantrine, mefloquine) It has and in contrast to these substances, never routinely been used as monotherapy in malaria. Degraded drugs were of good quality at the time of their manufacture, but have deteriorated since, often due to poor storage conditions. Given the hot and humid climate, drug stability and subsequent degradation would be expected to be an important problem in maintaining drug quality in sub-Saharan Africa This may be especially problematic for anti-malarial. Poor quality anti-malarial may result in under-dosing patients and subsequently lead to treatment failure or drug resistance by the parasite [14]. We evaluate and compare the effects of different storage temperature and ventilation conditions on International Journal of Biomedical Materials Research 2017; 5(3): 29-36 the active pharmaceutical ingredient (API) of an ACT- based antimalarial drug sold by drug vendors, availing public health stakeholders with information relevant to best storage practice for ACT- based antimalarial drugs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
