Abstract
Summary Pyrimidines can be degraded (1), reductively; (2), oxydatively by attack of oxygen in the position 5 or 6 of the pyrimidine ring; (3), by oxydative demethylation of thymine; (4), by decarboxylation of orotic acid to uracil; (5), by reductive degradation of orotic acid. The reductive degradation is the prevailing degrading process in nature. It is catalyzed by uracil reductase, dihydropyrimidinase and β-ureidopropionase. Properties and location of enzymes are described. Distribution and significance of pyrimidine degradation in different organisms are presented. Its presence in animals is preferentially discussed with respect to correlation between anabolic and catabolic reactions in terms of the “Molecular Correlation Concept”. Some plants use reverse reactions of pyrimidine degradation for biosynthesis of some pyrimidine-containing secondary products.
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