Abstract
The photosensitive pharmaceutical ingredient moxifloxacin hydrochloride degrades during storage under the influence of external factors, such as elevated temperature and ultraviolet and visible light irradiation, resulting in a decrease in the concentration of the active substance. To increase its resistance to these external factors, moxifloxacin hydrochloride was encapsulated in halloysite nanotubes. The aim of this study was to determine the level of degradation of moxifloxacin hydrochloride in its native and encapsulated states under the influence of temperature and ultraviolet and visible light irradiation. Encapsulation was carried out by the vacuum method and confirmed by TEM microscopy. The residual content of the photosensitive pharmaceutical ingredient after degradation was monitored by high-performance liquid chromatography of a model solution with an initial concentration of 2 mg/ml, prepared from samples of native and encapsulated moxifloxacin hydrochloride previously tested under the influence of temperature and light irradiation. Encapsulated moxifloxacin hydrochloride showed increased resistance to degradation caused by visible light irradiation at 200 watt-hours/m2 (by 10.9%); resistance to degradation was increased by 13.4% and 14% under test conditions during 24 hours of ultraviolet light irradiation and thermostating at a temperature of 600C, respectively, compared to non-encapsulated moxifloxacin hydrochloride.
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