Abstract
The present work had as its objective, the evaluation of the combination of electrochemical, photochemical and sonrochemical techniques (sono-electrochemical photoassisted) applied to degradation of cytarabine (chemotherapeutic drug) in a simulated urine that continues with creatinine and laboratory research. The paper involved laboratory research with both a qualitative and quantitative approach. A continuous-flow filter-press electrochemical reactor was employed using Dimensionally Stable Anode (DSA® - Ti/Ru0.3Ti0.7O2) as the electrode material. A 23 factorial design was used to optimize the degradation of organic compounds contained in artificial urine (creatinine and urea) together with cytarabine, varying applied current, retention time and flow rate, the response variable was total organic carbon (TOC) removal. Additionally, UHPLC analyses demonstrated the removal of ancitabine (precursor of cytarabine), corroborating with the data obtained by the from the experimental design. The use of artificial urine as an electronic support interferes with the electrochemical process, taking TOC to high levels. However, it was observed that there was significant removal of the organic load present in the effluent solution, even when a more complex degradation matrix is used (artificial urine).
Highlights
The increase in the number of people diagnosed with cancer is a reality experienced in several health units worldwide (Costa, 2010)
The present work had as its objective, the evaluation of the combination of electrochemical, photochemical and sonrochemical techniques applied to degradation of cytarabine in a simulated urine that continues with creatinine and laboratory research
A 23 factorial design was used to optimize the degradation of organic compounds contained in artificial urine together with cytarabine, varying applied current, retention time and flow rate, the response variable was total organic carbon (TOC) removal
Summary
The increase in the number of people diagnosed with cancer is a reality experienced in several health units worldwide (Costa, 2010). The higher incidence of cancer increases the consumption of anti-cancer drugs, as chemotherapy is one of the most frequently used treatment options (Shewach and Kuchta, 2009). Chemotherapy consists of the use of chemical compounds, called chemotherapeutics (Costa, 2010), known as cytotoxic or antineoplastic agents (Rabii, Segura, et al, 2014) primarily used in hospitals and are administered to outpatients and inpatients (Allwood, Stanley & Wright, 2002). In view of the above, the present study proposes the application of combined electrochemical, photochemical and ultrasound processes to promote the degradation of the cytarabine (chemotherapeutic drug), creatinine and urea in artificial urine, which is a highly complex degradation medium, and investigate the efficiency of this process for the treatment of effluents
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