Abstract
Lincomycin is one of the major species among the Pharmaceuticals and Personal Care Products (PPCPs) detectedfrom the four major rivers in Korea. The structure characterization was performed of six degradation products of lincomycinformed under the irradiation of electron beam, and the degradation efficiency as a function of the various irradiation dose andsample concentration was investigated. Electron beam (10 MeV, 0.5 mA and 5 kW) experiments for the structural characterizationof degradation products that are fortified with lincomycin, were performed at the dose of 10 kGy. The separation of degradationproducts and lincomycin was carried out using a C18 column (2.1×100 mm, 3.5 μm), using gradient elution with 20 mMammonium acetate and acetonitrile. The structures of six degradation products of lincomycin were proposed by interpretation ofmass spectra and chromatograms by LC-MS/MS. The mass fragmentation pathways of mass spectra in tandem mass spectrometrywere also proposed. Experiments were performed of the degradation efficiency as a function of the irradiation dose intensityand the initial concentration of lincomycin in an aqueous environment. In addition, increased degradation efficiency wasobserved with a higher dose of electron beam and lower concentration.
Highlights
Pharmaceuticals and personal care products (PPCPs) are a chemical group used extensively in medicines and personal hygiene products.[1]
Among the 30 Pharmaceuticals and Personal Care Products (PPCPs) surveyed in Korea, lincomycin was detected with relatively high concentration and frequency
This paper proposes the structures of the degradation products of lincomycin under an electron beam by the interpretation of mass spectra with LC-electrospray ionization (ESI)-MS/MS
Summary
Pharmaceuticals and personal care products (PPCPs) are a chemical group used extensively in medicines and personal hygiene products.[1] It is estimated that the number of PPCPs being used in the medical field exceeds 3000.2 Lincomycin is a well-established antibiotic pharmaceutical compound commonly used to control post-weaning diarrhea and effective against Gram-positive organisms in human and veterinary medicine. It is excreted in the urine as a mixture of the parent drug and its conjugated metabolite.[3,4].
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