Abstract
This study describes the development of Mg-Ca-La alloys with trace La addition for orthopedic application, which aims to control the biosafety and degradation simultaneously. The Mg-0.2Ca-0.2La alloy exhibited slow and uniform degradation with only 5.9% reduction in implant volume 12 weeks post-implantation. Cytocompatibility study, using MC3T3-E1, showed significantly higher cell proliferation and osteogenic differentiation on Mg-0.2Ca-0.2La alloy surface. When implanted in rat femur, significant bone growth with increased trabecular thickness and number was found around Mg-0.2Ca-0.2La rod. Moreover, no local or systematic adverse effect was observed during the implantation period.
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