Abstract
Rat sciatic nerves were exposed to injections of methylprednisolone acetate suspension (MPAS), the suspension vehicle without methylprednisolone, a local anesthetic (chloroprocaine 1%), and repeated needle punctures. The nerves were taken for histological study and compared with untreated controls. Nerves treated with the methylprednisolone suspension and its sterile vehicle showed similar incidence and severity of patchy degenerative changes, including demyelination, axonal disorganization, and endoneurial collagen formation. These findings suggest that repeated injections of MPAS near a peripheral nerve may cause nerve damage.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
