Abstract
Defragmentation in ablative AF treatment: is our knowledge too fragmented?
Highlights
Our current knowledge of the arrhythmic genesis of atrial fibrillation (AF) converges to the AF multiple wavelets concept of Moe and Allessie of the 1970s, which was further elaborated by many other investigators
Fragmented atrial signals and low electrogram voltages are often recordable in AF [3] for example after repair of congenital heart disease and various AF types and manifestations [2]
Most crucial for therapeutic application is their reproducible contribution to the onset and perpetuation of AF with critical conduction pathways
Summary
Our current knowledge of the arrhythmic genesis of atrial fibrillation (AF) converges to the AF multiple wavelets concept of Moe and Allessie of the 1970s, which was further elaborated by many other investigators. Fragmented atrial signals and low electrogram voltages are often recordable in AF [3] for example after repair of congenital heart disease and various AF types and manifestations [2]. T. de Bakker Department of Physiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands and 3D mapping raises questions such as their relation to the amount and depth of scarred tissue, stability during sinus rhythm (P wave characteristics) and/or other types of AF and/or atrial tachycardia.
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