Abstract
Purpose. To compare the impact of prognostic factors of patients treated with definitive radio(chemo)therapy versus patients treated with surgery and postoperative radiotherapy for squamous cell carcinoma of the oro- and hypopharynx. Patients and Methods. 162 patients treated with definitive radiotherapy and 126 patients treated with postoperative radiotherapy were retrospectively analysed. The impact of the prognostic factors gender, age, total tumor volume (TTV), pre-radiotherapy hemoglobin level (Hb-level), tumor site, T- and N-classification, radiotherapy interruptions >5 days, radiotherapy versus simultaneous radiochemotherapy, R-status and time interval between surgery and radiotherapy were investigated. Results. The median follow-up time for the censored patients treated with definitive radio(chemo)therapy was 28.5 months and for postoperative radiotherapy 36.5 months. On univariate analysis, the TTV, Hb-level, and simultaneous radiochemotherapy had a significant impact on the survival of patients treated with definitive radio(chemo)therapy. For patients treated with postoperative radiotherapy, only the TTV showed a statistical trend for the survival (P = 0.13). On multivariate analysis, the TTV and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (P = 0.19). Conclusions. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy.
Highlights
Squamous cell carcinoma of the head and neck (SCCHN) is the fifth most common neoplasm with an estimated annual global incidence of more than 500,000 cases diagnosed worldwide [1]
The total tumor volume (TTV) and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (P = 0.19)
The median follow-up time for the censored patients treated with definitive radiotherapy/radiochemotherapy was 28.5 months and for the patients treated with adjuvant postoperative radiotherapy 36.5 months
Summary
Squamous cell carcinoma of the head and neck (SCCHN) is the fifth most common neoplasm with an estimated annual global incidence of more than 500,000 cases diagnosed worldwide [1]. Single modality treatment is recommended for the patients with early-stage disease (stage I or stage II, approximately 40% of the patients with SCCHN) and combined modality treatment for patients with locally advanced disease. A precise understanding of prognostic factors is important to select the optimal treatment for the individual patient or to stratify patients for clinical trials or statistical analyses. In this retrospective single-institutional study, the role of potential prognostic factors was evaluated and compared in patients with squamous cell carcinoma of Journal of Oncology the oro- and hypopharynx after treatment with definitive radiotherapy/radiochemotherapy (dRT) versus surgery followed by postoperative radiotherapy (pRT)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
