Abstract
The mechanokinetic parameters characterising the force and power produced by fast (psoas) and slow (soleus) skeletal rabbit muscle are defined by feeding to a model simulation the mechanical output of a synthetic nanomachine (Pertici et al., Nat Commun 9:3532, 2018) powered by 8 heavy-mero-myosin fragments (HMM) of myosin II purified from either muscle. Implementation of a length clamp control for the minimization of the trap compliance allows to integrate the measurements of all the relevant steady state parameters (the isometric force (F0), the force-velocity relation and the maximum power (Pmax)) with transient kinetics parameters (rate of isometric force development (r) and force fluctuation due to individual motor attachment-detachment).
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