Abstract
Age-related macular degeneration (AMD) is a common, degenerative disease of the retina presented as neovascular AMD (n-AMD) or non‐neovascular AMD. Several factors risk factors having been found associated with unresponsive to treatment and progression macular scar form, including subtype of the choroidal neovascular membrane (CNM), presence of subretinal drusenoid deposits, Pigment epithelial detachment (PED), decreased central choroidal thickness, preexisting Macular atopy (MA) in the fellow eye. There is no exact consensus about the term described the status of poor or non- response to any treatment regime. In this article definition of different therapeutic responses such as resistance, refractory, recurrence of anti-vascular endothelial growth factors (AntiVEGF), and its relation to retinal features are discussed.
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