Abstract

The term “dyspepsia” applies to a wide variety of upper abdominal symptoms. The criteria for functional dyspepsia (FD) have undergone multiple revisions in the interest of achieving a reliable and useful definition for diagnostic, treatment, and research purposes. FD still includes a heterogeneous assortment of conditions, but four main symptoms have been identified through factor analysis as being reliable features of this diagnosis: bothersome postprandial fullness, early satiation, epigastric pain, and epigastric burning. Two subgroups, postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), were proposed in Rome III (2006) and its recent successor, Rome IV (2016). PDS is characterized by postprandial fullness and early satiation, while EPS is characterized by epigastric pain and epigastric burning. Epigastric pain and burning occurring after a meal is now considered a PDS symptom in Rome IV. Prevalence of FD is approximately 10–20% in Asia and is similar throughout the world. FD overlaps, to some extent, with both irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Pediatric FD is also defined by Rome IV.

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