Abstract
In skeletal muscle CaV1.1 functions as voltage-sensor of excitation contraction coupling (ECC). Upon membrane depolarization CaV1.1 activates the opening of RyR-1, leading to calcium release from the sarcoplasmic reticulum and consequently to muscle contraction. Upon intense depolarization, CaV1.1 can also elicit a voltage-dependent calcium current (ICa); however, with kinetics and voltage-dependence of activation distinct from those of ECC. These characteristic activation properties relate to the distinct roles of the four voltage sensing domains (VSD I-IV) of CaV1.1.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
