Abstract

Intrdouction: Diagnosis of acute cholangitis using Tokyo Guidelines 2018 (TG18) requires evidence of cholestasis. This is defined as hyperbilirubinemia or any liver enzyme derangement above 1.5 times the upper limit of normal - a rather broad inclusion criteria given that a cholestatic enzyme pattern is considered typical of biliary obstruction. The ratio of ALT and ALP elevation (R-value) characterizes cholestatic, hepatocellular, and mixed liver enzyme derangements. The pattern of liver enzyme derangement in acute cholangitis has not previously been defined.

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