Abstract
Evaluation of: Christensen TE, Callis CP, Papenfuss J et al. Observations of psoriasis in the absence of therapeutic intervention identifies two unappreciated morphologic variants, thin-plaque and thick-plaque psoriasis, and their associated phenotypes. J. Invest. Dermatol. 126, 2397–2403 (2006) .Psoriasis is a common immune-mediated inflammatory disease showing a variety of differing phenotypes. In the evaluated paper, attempts were made to classify plaque-psoriasis according to lesional thickness. It was noted that patients with thick plaques demonstrated obesity together with extensive body involvement. In addition, patients suffered from comorbidities including psoriatic arthritis. In contrast to thin or intermediate plaque thickness, patients with this phenotype suffer from lasting disease and a considerable inflammatory load, both of which could lead to the development of insulin resistance. As noted in studies of rheumatoid arthritis, chronic tumor necrosis factor α–regulated inflammation respresents a major cause for metabolic syndrome-related cardiovascular disease.
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