Abstract
The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants.
Highlights
The tractability of yeast for studies of meiosis has encouraged the search for mutants that might illuminate an elusive classical linkage phenomenon, crossover interference
The relationship between linkage map distance and crossover interference in creatures with two kinds of crossovers has been the subject of several statistical analyses (e.g. [5,6,7,8,9,10,11])
Where XI and XN are the contributions to the map length of the interfering and the noninterfering crossovers, respectively
Summary
The tractability of yeast for studies of meiosis has encouraged the search for mutants that might illuminate an elusive classical linkage phenomenon, crossover interference. Mutants that reduce interference as measured by the coefficient of coincidence [1] or the nonparental ditype (NPD) ratio ([2], [3]), might do so by reducing interference between the interfering crossovers, by reducing their frequency, by increasing the frequency of noninterfering crossovers, or by introducing population heterogeneity as a result of faulty effective pairing [4] or by combinations of these factors.
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