Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis.

Fabiana Rossi Varallo,Isabele Held Lemos,Rosa Camila Lucchetta,Marcela Forgerini,Sophia De Andrade Cavicchioli,Fernando Fernandez-Llimos,Mariane Nunes De Nadai,Ana Luísa Rodriguez Gini,Patricia De Carvalho Mastroianni

doi:10.1055/s-0042-1742409

Abstract

To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil. A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. Our review identified 31 studies, comprising 4,006 participants. All the studies had at least one weakness, mainly due to the use of convenience sampling and small sample size. The overall prevalence of vitamin D deficiency, insufficiency, and both deficiency and insufficiency were 35% (confidence interval, 95%CI: 34-37%), 42% (95%CI: 41-44%), and 72% (95%CI: 71-74%), respectively. Although the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems.

Highlights

The deficiency and insufficiency of 25-hydroxyvitamin D, known as 25(OH)D or vitamin D, is a worldwide issue: less than 50% of the world population has an adequate level of vitamin D, but in older people, pregnant women, and nonWestern immigrants the proportion is smaller.[1]
Conclusion the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems
Our systematic review identified 1,977 records in the electronic databases after duplicate removal (PubMed, LILACS, and Scopus) and 91 additional records identified through other sources

Summary

Introduction

The deficiency and insufficiency of 25-hydroxyvitamin D, known as 25(OH)D or vitamin D, is a worldwide issue: less than 50% of the world population has an adequate level of vitamin D, but in older people, pregnant women, and nonWestern immigrants the proportion is smaller.[1]. In Brazil, there is a great variability in studies assessing insufficiency and deficiency of vitamin D in women of childbearing age (12–68%),[17,18,19] but there is a lack of evidence that systematically summarizes their prevalence. A systematic review (2019) evaluated the deficiency and insufficiency of vitamin D in Brazil, with no specific analysis for women of childbearing age.[4] The present systematic review aimed to identify the prevalence and factors associated with inadequate levels of vitamin D in women of childbearing age in Brazil

Methods

Results

Discussion

Conclusion