Abstract
Objectives. Prevention of violations of microcirculation should take into account the massive entry of hemolysis products into the bloodstream and the related subsequent activation of free radical oxidation. Results. By simulating ischemia/reperfusion on rats we demonstrated the positive effect of deferoxamine on iron metabolism parameters (higher levels of transferrin, less ferritin and free iron, which received the drug group), also observed a decrease in the concentration of von Willebrand factor, as a measure of endothelial dysfunction. Blood viscosity parameters in the deferoxamine group was the closest to the control group parameters. Conclusion. Thus, we can conclude about the positive effect of deferoxamine on the parameters of iron metabolism, microcirculation and blood rheology in critical conditions involving ischemia/reperfusion.
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