Abstract
Deferasirox [Exjade, ICL 670], an oral once-daily iron chelator, was shown to be effective in the treatment of iron overload in both adults and children in studies presented at the 46th Annual Meeting of the American Society of Hematology (ASH) [San Diego, US; December 2004]. In a phase III study involving almost 600 patients with thalassaemia, deferasirox produced dose-dependent reductions in liver iron concentration (LIC), to levels comparable to those observed with the current standard therapy, deferoxamine. A phase II study showed that deferasirox reduced LIC in patients with myelodysplastic syndromes and Diamond-Blackfan syndrome, and in patients with thalassaemia who had inadequate chelation with deferoxamine.
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