Abstract
Secretory proteins destined for the lumen of the endoplasmic reticulum are key regulators of cellular functions and are thus subject to several levels of quality control. A recent study finds that the earliest step in secretory protein biogenesis--binding of the signal recognition particle to the signal sequence of the nascent peptide--is subject to a quality control process termed RAPP for 'regulation of aberrant protein production'. This process involves AGO2 and mRNA degradation.
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