Abstract
Monocyte migration was studied in 15 patients with newly diagnosed tuberculosis and 17 healthy control subjects matched for age, sex and ethnic group, using a raft modification of the Boyden chamber. Compared with matched controls, patients with tuberculosis exhibited impaired in vitro monocyte random locomotion and directional locomotion (chemotaxis) in response to 2% casein. However, no correlation was found between in vitro monocyte migration and monocyte count, radiological extent of disease or in vitro dermal reactivity to tuberculin-PPD. The observed defects were corrected during the course of chemotherapy.
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