Abstract
Metal-organic frameworks (MOFs) are considered highly promising nanomedicine carriers due to their well-defined structures, high specific surface area and porosity, adjustable pore size, and ease of chemical functionalization. However, traditional MOFs face limitations in lattice size and strong non-covalent interactions between the host and guest, posing significant challenges for high and responsive drug loading. In this study, defect-engineered MOFs (UiO-66-NH2) with uniform mesopores were successfully prepared by reducing ligands and adding modulators. Compared to perfect UiO-66-NH2, the loading capacity of the defective UiO-66-NH2 increased more than twofold. Utilizing phase change material as a trigger for drug release, precise temperature-responsive drug release was accomplished. This offers a novel strategy for MOFs materials in drug delivery and controlled release. This study will aid future efforts in using MOFs for selective drug delivery to cells, particularly in cancer treatment and related fields.
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