Abstract
Fibroblasts obtained from biopsied material and lymphocytes from patients wwith homocystinuria were studied for repair activity using the criterion of repair of DNA breaks induced by 4-nitroquinoline 1-oxide and γ-irradiation and criteria of reactivation and induced mutagenesis of vaccinia virus. Lymphocytes showed defective DNA repair for all these criteria. In fibroblast cultures, the inhibition of cell-repair activity for the γ-type was retained. The number of spontaneous and γ-induced virus mutations increased as passaging of fibroblasts proceeded.
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