Abstract
Abstract 1. 1. Fibroblastic cell cultures were derived from the anterior rectus sheath of one control patient, two men with indirect, and three with direct inguinal herniation. The rates of cell proliferation were studied up to thirty-nine days. The results obtained through regression equations indicated that the rate of cell proliferation is decreased among cells derived from patients with herniation as compared to that of a control. The order of decrease corresponded to the type of herniation. The average generation time was about one and a half times longer for cells obtained from herniated tissue as compared to that of normal cells. 2. 2. In vitro studies pertaining to the rates of incorporation of radioactively-labeled proline into the anterior rectus sheath of patients with and without herniation revealed that the incorporation of proline was significantly lower in the rectus sheath from patients with hernias as compared to that of normal tissue. The least incorporation was observed in direct herniation. 3. 3. From these observations it is suggested that the cause of herniation in the adult lies in a reduced collagen synthesis by the fibroblasts, thus rendering the abdominal aponeuroses weaker.
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