Abstract
A male infant with severe recurrent and chronic staphylococcal infections, disseminated cytomegalovirus infection, and autoimmune reactions was found to have an impairment of neutrophil motility. In vitro studies revealed that the abnormality was due to an inhibitor in serum but not in plasma. The inhibitory effect of the patient's serum was antagonized by normal plasma but not by the patient's plasma. Furthermore, after transfusion of normal blood or plasma, the clinical condition imporved dramatically and neutrophils were found in skin lesions where they were previously absent. It was concluded that the basic defect was the absence of a normal antagonist to a serum inhibitor of neutrophil motility. This is the second reported case of an absence of this antagonist.
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