Abstract
In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. For using nanoparticles for biomedical purposes is implemented a technique for coating nanoparticles with polymers, such as PEG and PSA. This approach provides low non-specific adsorption, which prolongs the circulation of UCNPs in mouse bearing Lewis Lung Cancer (LLC) up to 10 hours. These properties allow nanoparticles to quickly accumulate in the tumor. Effective delivery of particles with different polymer coatings in the tumor is demonstrated with the help of an epiluminescent imaging system.
Highlights
In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor
The wavelength of excitation and photoluminescence UCNPs falls into the so-called "window of biotissue transparency", which allows them to be visualized in biological tissues from a depth of several centimetre [2]
To improve the targeted delivery and reduce non-specific absorption by macrophages, we modified their surface with hydrophilic biocompatible coatings based on polyethylene glycol (PEG) and polysialic acid (PSA), which increased the circulation time in the bloodstream from several minutes to 10 hours (Fig.1A)
Summary
In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. Such nanoparticles are able to label tumor tissues and ensure their visualization in real time [1]. UCNPs are characterized by photostability, low toxicity, and their surface, allows the creation of conjugates with targeting modules.
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